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(A) MDS-UPDRS part III score: mean change from T0. (B) Pull test score (blinded rating): mean change from T0. Compared with that in the control group (interrupted line), the change between T0 and T2 was superior in the INSTR group (solid line); *p < 0.05, **p < 0.01 in ANCOVA. MDS-UPDRS, Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale; ANCOVA, analysis of covariance.
