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. 2022 Jun 23;17(7):1620–1635. doi: 10.1016/j.stemcr.2022.05.015

Figure 6.

Figure 6

Direct conversion of human neonatal, adult, and aged fibroblasts to induced astrocytes

(A and B) Immunofluorescence images of human neonatal and adult fibroblasts (38–96 years) 3 weeks after induction of SAB or SB (A) or freshly prepared SB (B).

(C) Glutamate uptake of SB-infected HEFs and human adult fibroblasts (38 years) at 5 weeks.

Individual color levels are adjusted for visibility in (A) and (B). Data are presented as mean ± SEM of n = 4 parallel independent experiments. Two-tailed Wilcoxon matched-pairs rank test with significance level p < 0.05 was performed for statistical analysis in (C). Scale bars, 50 μm (A) and 20 μm (B).