Table 1.

Criteria for diagnosis of Sweet’s syndrome

Criteria for diagnosis of classic and drug-induced Sweet’s syndrome
Major criteria
1. Abrupt onset of typical cutaneous lesions (tender erythematous plaques or nodules, occasionally with vesicles, pustules, or blisters)   2. Histopathology consistent with Sweet’s syndrome (predominantly neutrophilic dermal infiltrate without leukoclastic vasculitis)
Minor criteria
1. Preceded by an associated infection (gastrointestinal or respiratory) or vaccination or associated with     - Inflammatory diseases such as chronic autoimmune disorders, infections     - Hemoproliferative disorders or solid malignant tumor     - Pregnancy   2. Presence of fever (> 38 °C)   3. Abnormal laboratory values     - Erythrocyte sediment rate > 20 mm/h     - Elevated C-reactive protein levels     - Leukocytosis > 8000     - Neutrophilic > 70%   4. Excellent response to systemic corticosteroids

Criteria for diagnosis of drug-induced Sweet’s syndrome

1. Abrupt onset of painful erythematous plaques or nodules   2. Histopathological evidence of a dense neutrophilic infiltrate without evidence of leukoclastic vasculitis   3. Presence of fever (38 °C)   4. Temporal relationship between drug ingestion and clinical presentation or temporally related recurrence after oral challenge   5. Temporally related resolution of lesions after drug withdrawal or treatment with systemic corticosteroids

In order for the diagnosis of SS, including classic SS and/or malignancy-associated SS, both major criteria along with at least two minor criteria must be met. For drug-induced SS, all five criteria must be met for diagnosis