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. 2022 Jul 16;8:324. doi: 10.1038/s41420-022-01122-1

Fig. 4. Antiviral response in the platelet proteome.

Fig. 4

A PPI is related to the response through type-I interferon. Each color represents a different EP/DEP classification: purple EPs represent PPIs described in the COVID-19 group. The EPs IFIT1 and 3, EPs from the COVID-19 group, and a DEP exclusive to the survivor group subset are represented in pink. The DEPs from the COVID-19 group are displayed in light pink. Last, the validated proteins ISG-15 and IFITM-1, both EPs from the COVID-19 group, are represented in red. All DEPs were shown to be upregulated. B Western blot analysis of ISG-15 and β-actin in platelets isolated from three healthy volunteers (controls) and nine patients with severe COVID-19. C Western blot analysis of IFITM-1 and β-actin in platelets isolated from three controls and nine patients with severe COVID-19. The densitometric analyses of each band are represented in a graph. The boxes indicate the median and interquartile ranges, and whiskers indicate minimal and maximal values in each group. *p < 0.05 between controls and severe COVID-19 patients (unpaired t test).