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. 2022 Jul 16;8:324. doi: 10.1038/s41420-022-01122-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A PPI is related to mRNA translation and structural constituents of ribosomes. Circles in dark orange represent EPs from nonsurvivors; circles in light orange represent DEPs more abundant in the overall COVID-19 group. B Platelet viral loads in severe cases of COVID-19, by endpoint: survivors or nonsurvivors. No significant differences were found between endpoints (Mann–Whitney U = 11, P = 0.8413, ns). C SARS-CoV-2 genome coverage graphs of platelet samples. Platelet RNA was submitted to SARS-CoV-2 target sequencing to screen for viral genome presence, whether total or partial. A scheme of the Wuhan-Hu-1 genomic isolate [GenBank: NC_045512.2], spanning all structural and nonstructural components, is represented with coverage graphs (blue) for each sample [GenBank: OL984052; OL984053; OL986402; OL984057; OL984061]. Dotted lines mark read depths equal to 100.