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. 2022 Jun 24;54:102384. doi: 10.1016/j.redox.2022.102384

Fig. 13.

Fig. 13

Effect of MSN-NGR1-CD11b antibody nanoparticles injected intravenously on PI3K/AKT, ERK1/2 and YAP signaling pathways. The levels of p-AKT and p-ERK1/2 were detected by WB (A–D). *P < 0.05, **P < 0.01 versus the MI group; ##P < 0.01 versus the MI + MSN-NGR1 group. AKT and ERK pathway could be obviously activated in cardiomyocytes according to immunofluorescence double labeling of cTnT + p-AKT or cTnT + p-ERK1/2 (E, F). Immunofluorescence staining to detect the YAP nuclear translocation (G). Scale bar: 25 μm. The levels of cytoplasmic and nuclear YAP were detected by WB (H). *P < 0.05 versus the MI group; #P < 0.05 versus the MI + MSN-NGR1 group.