Table 1.
ED50 values of THC and Morphine. ED50 was calculated for the time point in which maximal effects were observed.
| Drug | Outcome | Time | Sex | ED50: mg/kg (95%CI) |
|---|---|---|---|---|
| Morphine | Tail Flick (%MPE) | 30-min | M | 9.00 (5.5-9.5) |
| F | 4.76 (3.8-5.3) | |||
| Von Frey (%MPE) | 45-min | M | 2.42 (0.0-7.5) | |
| F | 2.96 (1.0-6.2) | |||
| THC | Tail Flick (%MPE) | 300-min | M | 1.66 (0.5-4.3) |
| F | 4.34 (1.6-10.7)* | |||
| Von Frey (%MPE) | 135-min | M | 4.32 (1.9-9.0) | |
| F | 6.40 (3.3-12.6) | |||
| Hypothermia (Δ°C) | 420-min | M | 4.54 (2.1-9.7) | |
| F | 11.14 (6.5-19.8) | |||
| Hyperlocomotion (% Vehicle) | 30-min | M | 4.57 (1.2-15.4) | |
| F | 4.23 (1.4-11.9) | |||
| Hypolocomotion (% Vehicle) | 270-min | M | 2.19 (0.5-7.1) | |
| F | 1.81 (0.0-13.4) | |||
| Catalepsy (ln(s)) | 330-min | M | 9.47 (2.3-56.2) | |
| F | 7.53 (4.2-13.8) |
An asterisk (*) is used to denote non-overlapping 95% confidence intervals between males and females.