Table 2.
Summary of QTL detected for birth weight in U.S. Red Angus cattle
| Chr_Mba | -log10 P-value | Regression Beta | MAFb | Supporting SNPsc | Positional Candidate Genes | Lead SNP Location | Scientific Precedence [reference]; organism; trait |
|---|---|---|---|---|---|---|---|
| 6_38 | 67.949 | −3.123 | 0.283 | 102 | LCORL, LOC782905 | Intergenic | [20, 24, 26, 37–45]; Cattle; Birth, weaning and yearling weight, fat and protein percentage, carcass weight, fat thickness, dystocia, average daily gain and dry matter intake, hip height, ribeye area, calving ease, stature, feed intake and gain |
| 6_37 | 47.734 | −2.302 | 0.359 | 183 | NCAPG | Exond | [20, 24, 39, 40, 42–45]; Cattle; Weaning and yearling weight, calving ease, dystocia, average daily gain, dry matter intake, fetal growth, daily feed intake, muscle growth |
| 14_23 | 38.772 | 2.800 | 0.110 | 64 | PLAG1 | 3’UTR | [11, 20, 24, 26, 31, 46]; Cattle; Birth weight, mid-test metabolic weight, yearling and carcass weight, stature, milk protein yield, stature |
| 20_05 | 31.330 | 1.815 | 0.436 | 100 | LOC104975192, STC2 | Intergenic | [20, 24, 31, 40, 42, 47, 48]; Cattle; Birth, weaning and carcass weight, average daily gain, dry matter intake, stature, mature rate, mid-test metabolic weight |
| 6_36 | 26.156 | −2.267 | 0.219 | 63 | HERC6 | Intron | [20, 40, 42, 49–51]; Cattle; Birth, weaning, and yearling weight, mature weight, average daily gain, dry matter intake, backfat thickness, conception rate, milk production traits, protein ubiquitination |
| 14_24 | 25.908 | 2.143 | 0.113 | 80 | LOC112449660, IMPAD1 | Intergenic | [20, 24, 26, 29, 31, 46]; Cattle; Birth, weaning, and yearling weight, calving ease, carcass weight, milk and protein yield, stature, stillbirth, body size, mid-test metabolic weight |
| 6_39 | 21.788 | −1.569 | 0.270 | 35 | LOC782905, SLIT2 | Intergenic | [20, 24, 37, 40, 42, 52]; Cattle; Birth, weaning, and yearling weight, calving ease, carcass weight, average daily gain, dry matter intake, backfat thickness, ribeye area, hip height |
| 7_91 | 17.095 | 1.339 | 0.263 | 70 | LOC101905238, ARRDC3 | Intergenic | [24, 30, 31, 46, 53]; Cattle; Milk protein yield, chest width and bone quality, calving ease, average daily gain, growth and muscularity, birth, weaning, and yearling weight, ribeye area |
| 20_06 | 15.122 | −1.372 | 0.382 | 12 | LOC783392, CPEB4 | Intergenic | [40, 48, 49, 54, 55]; Cattle; Fat percentage, dry matter intake, mature weight, conception rate, mRNA and protein expression in meiosis regulation |
| 6_35 | 14.833 | −1.305 | 0.317 | 32 | MMRN1 | Exone | [24, 43, 56–58]; Cattle, human, sheep; Birth weight, dry matter intake, fetal growth, weaning weight, winter tolerance under metabolic stress response |
| 6_40 | 14.409 | 2.002 | 0.060 | 47 | SLIT2 | Intron | [20, 24, 40, 42, 59, 60]; Cattle, mouse; Birth, weaning, and yearling weight, calving ease, average daily gain, carcass weight, hip height, milk fat and protein, development of central nervous system |
| 20_04 | 11.639 | −1.088 | 0.438 | 12 | SH3PXD2B | Intron | [24, 40, 61]; Cattle, human; Birth and weaning weight, carcass weight, fat thickness, calving ease, average daily gain, development of eyes, heart, and bone |
| 6_41 | 11.067 | 1.171 | 0.264 | 57 | KCNIP4 | Intron | [20, 24, 38, 40, 42, 62, 63]; Cattle, human; Birth, weaning, and yearling weight, protein percentage, average daily gain, ribeye area, carcass weight, milk fatty acid composition, potassium channel activity |
| 6_32 | 9.335 | 0.985 | 0.325 | 57 | GRID2 | Intron | [40, 42, 46, 64]; Human, cattle; Mammalian nervous system mediation, dry matter intake, average daily gain, birth weight, milk fat yield |
| 6_34 | 8.662 | −1.095 | 0.285 | 14 | CCSER1 | Intron | [20, 49, 58, 65]; Cattle, human, sheep; Birth and weaning weight, conception rate, regulator of mitosis, feed intake |
| 14_25 | 6.648 | 0.805 | 0.311 | 41 | NSMAF, LOC107133116 | Intergenic | [20, 24, 29, 31, 40, 47, 59, 66, 67]; Cattle, human; Birth, weaning, and yearling weights, calving ease, carcass weight, average daily gain, dry matter intake, hip height, stature, backfat thickness, ribeye area, lean meat yield, stillbirth, residual feed intake, immune system response |
| 20_07 | 6.424 | 0.725 | 0.378 | 26 | ENC1, LOC112443028 | Intergenic | [49, 68, 69]; Cattle, mouse; Conception rate, residual feed intake, development of nervous system |
| 14_22 | 5.827 | −1.153 | 0.068 | 15 | LOC101906669, TRNAG-UCC | Intergenic | [11, 40, 41]; Cattle; Average daily gain, hip height, protein percentage |
| 14_02 | 5.239 | 0.762 | 0.124 | 5 | SLURP1 | 3’UTR | [49, 54, 70]; Rat, cattle; Immune response, protein, fat and milk yield, fat and protein percentage, number of breedings until conception |
a Chromosome_Megabase
b Minor Allele Frequency
c Single Nucleotide Polymorphisms
d Indicates a predicted nonsynonymous mutation Ile➔Met, exon 9
e Indicates a predicted nonsynonymous mutation Gln➔His, exon 6