Table 3.
Summary of QTL detected for weaning weight in U.S. Red Angus cattle
| Chr_Mba | -log10 P-value | Regression Beta | MAFb | Supporting SNPsc | Positional Candidate Genes | Lead SNP Location | Scientific Precedence [reference]; organism; trait |
|---|---|---|---|---|---|---|---|
| 6_38 | 25.669 | −10.153 | 0.283 | 66 | LCORL, LOC782905 | Intergenic | [20, 24, 26, 37–45]; Cattle; Birth, weaning and yearling weight, fat and protein percentage, carcass weight, fat thickness, dystocia, average daily gain and dry matter intake, hip height, ribeye area, calving ease, stature, feed intake and gain |
| 6_37 | 21.575 | −8.352 | 0.328 | 121 | FAM184B | Intron | [20, 24, 39, 40, 42]; Cattle; Weaning and yearling weights, calving ease, dystocia, average daily gain, dry matter intake, daily feed intake |
| 20_05 | 21.392 | −7.859 | 0.444 | 94 | LOC104975192, STC2 | Intergenic | [20, 24, 31, 40, 42, 47, 48]; Cattle; Birth, weaning and carcass weight, average daily gain, dry matter intake, stature, mature rate, mid-test metabolic weight |
| 6_36 | 16.846 | − 9.442 | 0.219 | 30 | HERC6 | Intron | [20, 40, 42, 49–51]; Cattle; Birth, weaning, and yearling weight, mature weight, average daily gain, dry matter intake, backfat thickness, conception rate, milk production traits, protein ubiquitination |
| 6_35 | 11.962 | −5.632 | 0.356 | 26 | LOC112447052 | Intron | [24, 40, 43, 56]; Cattle; Birth weight, dry matter intake, fetal growth, weaning weight |
| 20_06 | 10.817 | − 5.963 | 0.385 | 7 | NSG2 | 3’UTR | [40, 48, 49, 54, 73]; Cattle, mouse; Fat percentage, dry matter intake, mature weight, conception rate, synapse formation and maintenance |
| 14_23 | 10.334 | 7.667 | 0.110 | 47 | LOC112449630, MOS | Intergenic | [11, 20, 24, 26, 46]; Cattle; Birth, yearling and carcass weights, milk protein and fat yield, stature |
| 6_34 | 8.719 | − 5.723 | 0.286 | 21 | CCSER1 | Intron | [20, 49, 58, 65]; Cattle, human, sheep; Birth and weaning weight, conception rate, regulator of mitosis, feed intake |
| 6_39 | 8.370 | −5.285 | 0.270 | 21 | LOC782905, SLIT2 | Intergenic | [20, 24, 37, 40, 42, 52]; Cattle; Birth, weaning, and yearling weight, calving ease, carcass weight, average daily gain, dry matter intake, backfat thickness, ribeye area, hip height |
| 20_04 | 8.218 | −4.810 | 0.438 | 12 | SH3PXD2B | Intron | [24, 40, 61]; Cattle, human; Birth and weaning weights, carcass weight, fat thickness, calving ease, average daily gain, development of eyes, heart, and bone |
| 14_24 | 6.670 | 6.144 | 0.099 | 31 | PENK, LOC112449660 | Intergenic | [20, 24, 26, 29, 31, 46, 74]; Cattle, rat; Birth, weaning, and yearling weights, calving ease, carcass weight, milk and protein yield, stillbirth, body size, mid-test metabolic weight, bone development |
| 6_40 | 5.810 | 6.922 | 0.060 | 5 | SLIT2 | Intron | [20, 24, 40, 42, 59, 60]; Cattle, mouse; Birth, weaning, and yearling weight, calving ease, average daily gain, carcass weight, hip height, milk fat and protein, development of central nervous system |
| 7_90 | 5.781 | −5.278 | 0.097 | 5 | MIR3660, CETN3 | Intergenic | [42, 49, 75–77]; Cattle, human, mice; Birth and yearling weights, conception rate, cell proliferation control, insulin response, cell regulation, centriole duplication and mitosis in embryonic development |
| 6_32 | 5.366 | 4.287 | 0.277 | 26 | GRID2 | Intron | [40, 42, 46, 64]; Human, cattle; Mammalian nervous system mediation, dry matter intake, average daily gain, birth weight, milk fat yield |
a Chromosome_Megabase
b Minor Allele Frequency
c Single Nucleotide Polymorphisms