Table 4.

Summary of QTL detected for yearling weight in U.S. Red Angus cattle

Chr_Mba	-log10 P-value	Regression Beta	MAFb	Supporting SNPsc	Positional Candidate Genes	Lead SNP Location	Scientific Precedence [reference]; organism; trait
6_38	48.689	−24.991	0.282	87	LCORL, LOC782905	Intergenic	[20, 24, 26, 37–45]; Cattle; Birth, weaning and yearling weight, fat and protein percentage, carcass weight, fat thickness, dystocia, average daily gain and dry matter intake, hip height, ribeye area, calving ease, stature, feed intake and gain
6_37	36.517	−19.339	0.328	173	FAM184B	Intron	[20, 24, 39, 40, 42]; Cattle; Weaning and yearling weights, calving ease, dystocia, average daily gain, dry matter intake, daily feed intake
20_05	34.429	−18.105	0.441	116	STC2	Exond	[20, 24, 31, 40, 42, 47, 48]; Cattle; Birth, weaning and carcass weight, average daily gain, dry matter intake, stature, mature rate, mid-test metabolic weight
6_36	25.670	−21.048	0.219	49	HERC6	Intron	[20, 40, 42, 49–51]; Cattle; Birth, weaning, and yearling weight, mature weight, average daily gain, dry matter intake, backfat thickness, conception rate, milk production traits, protein ubiquitination
6_39	19.104	−14.508	0.271	45	LOC782905, SLIT2	Intergenic	[20, 24, 39, 42, 44, 54]; Cattle; Birth, weaning, and yearling weight, calving ease, carcass weight, average daily gain, dry matter intake, backfat thickness, ribeye area, hip height
14_23	16.513	17.008	0.116	47	PLAG1	3’UTR	[11, 20, 24, 26, 31, 46]; Cattle; Birth weight, mid-test metabolic weight, yearling and carcass weight, stature, milk protein yield, stature
20_06	15.250	−12.790	0.390	24	LOC783392, CPEB4	Intergenic	[40, 48, 49, 54, 55]; Cattle; Fat percentage, dry matter intake, mature weight, conception rate, mRNA and protein expression in meiosis regulation
6_40	13.214	−11.340	0.276	69	KCNIP4	Intron	[20, 24, 42, 56, 59, 60, 63, 66]; Cattle, mouse, human; Birth, weaning, and yearling weights, calving ease, mature weight, average daily gain, carcass weight, hip height, post-weaning weight, liver weight, potassium channel function
6_35	12.635	−11.427	0.315	40	MMRN1	Exone	[24, 43, 56–58]; Cattle, human, sheep; Birth weight, dry matter intake, fetal growth, weaning weight, winter tolerance under metabolic stress response
6_34	12.607	−12.734	0.286	36	CCSER1	Intron	[20, 49, 58, 65]; Cattle, human, sheep; Birth and weaning weight, conception rate, regulator of mitosis, feed intake
14_24	12.459	14.915	0.102	42	PENK, LOC112449660	Intergenic	[20, 24, 26, 29, 31, 46, 74]; Cattle, rat; Birth, weaning, and yearling weights, calving ease, carcass weight, milk and protein yield, stillbirth, body size, mid-test metabolic weight, bone development
20_04	10.984	−10.008	0.442	25	SH3PXD2B	Intron	[24, 40, 61]; Cattle, human; Birth and weaning weights, carcass weight, fat thickness, calving ease, average daily gain, development of eyes, heart, and bone
6_41	10.036	8.987	0.486	41	KCNIP4	Intron	[20, 24, 38, 40, 42, 62, 63]; Cattle, human; Birth, weaning, and yearling weight, protein percentage, average daily gain, ribeye area, carcass weight, milk fatty acid composition, potassium channel activity
6_33	9.693	−9.134	0.299	6	CCSER1	Intron	[24, 49, 65]; Cattle, human; Carcass weight, fat thickness, conception rate, regulator of mitosis
7_91	8.726	8.879	0.240	39	LOC112447488, LOC112447489, LOC101905238, ARRDC3	Intergenic	[24, 30, 31, 46, 53]; Cattle; Milk protein yield, chest width and bone quality, calving ease, average daily gain, growth and muscularity, birth, weaning, and yearling weight, ribeye area
20_03	8.002	7.171	0.472	6	KCNIP1	Intron	[78]; Frog, zebrafish; Development of neural plate, associated with cardiac myocytes

^a Chromosome_Megabase

^b Minor Allele Frequency

^c Single Nucleotide Polymorphisms

^d Indicates a predicted nonsynonymous mutation Pro➔Ala, exon 2

^e Indicates a predicted nonsynonymous mutation Gln➔His, exon 6