Table 4.
Summary of QTL detected for yearling weight in U.S. Red Angus cattle
Chr_Mba | -log10 P-value | Regression Beta | MAFb | Supporting SNPsc | Positional Candidate Genes | Lead SNP Location | Scientific Precedence [reference]; organism; trait |
---|---|---|---|---|---|---|---|
6_38 | 48.689 | −24.991 | 0.282 | 87 | LCORL, LOC782905 | Intergenic | [20, 24, 26, 37–45]; Cattle; Birth, weaning and yearling weight, fat and protein percentage, carcass weight, fat thickness, dystocia, average daily gain and dry matter intake, hip height, ribeye area, calving ease, stature, feed intake and gain |
6_37 | 36.517 | −19.339 | 0.328 | 173 | FAM184B | Intron | [20, 24, 39, 40, 42]; Cattle; Weaning and yearling weights, calving ease, dystocia, average daily gain, dry matter intake, daily feed intake |
20_05 | 34.429 | −18.105 | 0.441 | 116 | STC2 | Exond | [20, 24, 31, 40, 42, 47, 48]; Cattle; Birth, weaning and carcass weight, average daily gain, dry matter intake, stature, mature rate, mid-test metabolic weight |
6_36 | 25.670 | −21.048 | 0.219 | 49 | HERC6 | Intron | [20, 40, 42, 49–51]; Cattle; Birth, weaning, and yearling weight, mature weight, average daily gain, dry matter intake, backfat thickness, conception rate, milk production traits, protein ubiquitination |
6_39 | 19.104 | −14.508 | 0.271 | 45 | LOC782905, SLIT2 | Intergenic | [20, 24, 39, 42, 44, 54]; Cattle; Birth, weaning, and yearling weight, calving ease, carcass weight, average daily gain, dry matter intake, backfat thickness, ribeye area, hip height |
14_23 | 16.513 | 17.008 | 0.116 | 47 | PLAG1 | 3’UTR | [11, 20, 24, 26, 31, 46]; Cattle; Birth weight, mid-test metabolic weight, yearling and carcass weight, stature, milk protein yield, stature |
20_06 | 15.250 | −12.790 | 0.390 | 24 | LOC783392, CPEB4 | Intergenic | [40, 48, 49, 54, 55]; Cattle; Fat percentage, dry matter intake, mature weight, conception rate, mRNA and protein expression in meiosis regulation |
6_40 | 13.214 | −11.340 | 0.276 | 69 | KCNIP4 | Intron | [20, 24, 42, 56, 59, 60, 63, 66]; Cattle, mouse, human; Birth, weaning, and yearling weights, calving ease, mature weight, average daily gain, carcass weight, hip height, post-weaning weight, liver weight, potassium channel function |
6_35 | 12.635 | −11.427 | 0.315 | 40 | MMRN1 | Exone | [24, 43, 56–58]; Cattle, human, sheep; Birth weight, dry matter intake, fetal growth, weaning weight, winter tolerance under metabolic stress response |
6_34 | 12.607 | −12.734 | 0.286 | 36 | CCSER1 | Intron | [20, 49, 58, 65]; Cattle, human, sheep; Birth and weaning weight, conception rate, regulator of mitosis, feed intake |
14_24 | 12.459 | 14.915 | 0.102 | 42 | PENK, LOC112449660 | Intergenic | [20, 24, 26, 29, 31, 46, 74]; Cattle, rat; Birth, weaning, and yearling weights, calving ease, carcass weight, milk and protein yield, stillbirth, body size, mid-test metabolic weight, bone development |
20_04 | 10.984 | −10.008 | 0.442 | 25 | SH3PXD2B | Intron | [24, 40, 61]; Cattle, human; Birth and weaning weights, carcass weight, fat thickness, calving ease, average daily gain, development of eyes, heart, and bone |
6_41 | 10.036 | 8.987 | 0.486 | 41 | KCNIP4 | Intron | [20, 24, 38, 40, 42, 62, 63]; Cattle, human; Birth, weaning, and yearling weight, protein percentage, average daily gain, ribeye area, carcass weight, milk fatty acid composition, potassium channel activity |
6_33 | 9.693 | −9.134 | 0.299 | 6 | CCSER1 | Intron | [24, 49, 65]; Cattle, human; Carcass weight, fat thickness, conception rate, regulator of mitosis |
7_91 | 8.726 | 8.879 | 0.240 | 39 | LOC112447488, LOC112447489, LOC101905238, ARRDC3 | Intergenic | [24, 30, 31, 46, 53]; Cattle; Milk protein yield, chest width and bone quality, calving ease, average daily gain, growth and muscularity, birth, weaning, and yearling weight, ribeye area |
20_03 | 8.002 | 7.171 | 0.472 | 6 | KCNIP1 | Intron | [78]; Frog, zebrafish; Development of neural plate, associated with cardiac myocytes |
a Chromosome_Megabase
b Minor Allele Frequency
c Single Nucleotide Polymorphisms
d Indicates a predicted nonsynonymous mutation Pro➔Ala, exon 2
e Indicates a predicted nonsynonymous mutation Gln➔His, exon 6