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. 2022 Jul 16;20:105. doi: 10.1186/s12964-022-00882-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visithttp://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Penfluridol in combination with CC effectively suppresses the tumor xenografts in vivo. A The working model shows the process of our animal studies. Mice were transplanted with tumor tissues for 10 days and randomly divided into four groups (control, CC (10 mg/kg), PF (10 mg/kg), CC + PF; n = 5/group). Then, the tumor-bearing mice were treated with intragastric administration and intratumor injection with a dissolvent, intratumor injection with CC, intragastric administration with PF, and CC + PF co-treatment. All mice were sacrificed on day 15, and the tumors were collected for subsequent experiments. B The body weight change of mice after indicated treatment. C Tumor weight of the mice. D Tumor growth curves of tumor tissues after indicated treatment. E Photograph of the transplanted tumors after indicated treatment. F Western blotting assay result of the tumors with indicated treatment. G The H&E results and IHC staining assay for Ki-67, Cleaved-caspase3, p-AMPK T172 of the tumors. **P < 0.01, ****P < 0.0001