Fig. 7.

Nilotinib reduces LPS-evoked c-Abl levels in the brain in wild-type mice. a Immunofluorescence staining of c-Abl expression in brain slices from wild-type mice injected with vehicle (5% DMSO, 10% PEG and 20% Tween 80 in deionized water) or nilotinib (20 mg/kg, i.p.) daily for 7 days followed by LPS (10 mg/kg, i.p.) or PBS on day 7. b Quantification of the data in a (n = 12–23 brain slices from 3–4 mice/group). c Western blotting analysis of c-Abl protein levels in the cortex and hippocampus (n = 4/group). *p < 0.05, **p < 0.01, ***p < 0.001. Scale bar = 100 μM