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Widespread mucosal injury in COVID-19. A, Small intestinal biopsy in a patient with COVID-19 demonstrates villous blunting with cuboidalization and attenuation of the duodenal enterocytes, and crypt hyperplasia. B, A biopsy of the colon in the same patient shows cuboidal, disarrayed colonocytes with attenuated crypts and increased cellularity of the lamina propria. A few crypts (such as the one at left) show sloughed epithelial cells within the crypt. (Courtesy of Dr. Rhonda Yantiss).
