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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Nature. 2022 Apr 28;606(7914):585–593. doi: 10.1038/s41586-022-04802-1

Extended data figure 11. SARS-CoV-2 infected human macrophages have a unique transcriptional signature (matched to figure 3).

Extended data figure 11.

a. Representative gating strategy of CXCL10 or TNF producing human macrophages in MISTRG6-hACE2 mice infected with SARS-CoV-2-mNG.

b. Representative flow cytometry plots of CXCL10 and TNF staining in mice therapeutically treated with mAb or control untreated mice. Representative of n=4 biologically independent mice.

C. CXCL10 production measured by ELISA in supernatants of BMDMs infected with SARS- CoV-2 in vitro. Infected BMDM cultures were supplemented with pooled plasma from COVID-19 and were treated with Remdesivir or not. Uninfected n=5, CTRL infected n=12, RDV n=4 over 3 independent experiments. Means with individual values are plotted. Unpaired, two-tailed t-test.

c. Spearman correlation values of each gene based on its correlation with CXCL10 or TNF or TLR7.

d. Expression and distribution of CXCL10, TNF and TLR7 in human immune cells from infected (4, 14 and 28dpi) MISTRG6-hACE2 mice.