Table 1.
Demographics and characteristics of severe COVID-19 patients in 1-year follow-up
| Variables | Follow-up after 1 year | |||
|---|---|---|---|---|
| Total patients (n = 25) | hUC-MSCs (n = 8) | Control (n = 17) | P value# | |
| Age, years, median (IQR) | 51.00 (45.00,67.00) | 50.50 (39.00, 72.75) | 52.00 (45.00,63.00) | 0.521 |
| Male | 11 (44.00%) | 4 (50.0%) | 7 (41.18%) | 1.000 |
| Smokers | 7 (28.00%) | 3 (37.5%) | 4 (23.53%) | 0.640 |
| Body mass index (BMI) | 26.08 (22.16,27.99) | 22.91 (20.40, 24.43) | 26.08 (21.51,27.99) | 0.181 |
| Diabetes/hypertension | 10 (40.00%) | 4 (50.0%) | 6 (35.29%) | 0.667 |
| Blood routine examination | ||||
| WBC, median (IQR), 109 /L | 5.60 (4.79,6.07) | 5.62 (4.98,6.27) | 5.60 (4.73,6.07) | 0.813 |
| NEU, 109 /L | 3.24 (2.65,3.84) | 3.05 (2.24,4.15) | 3.27 (2.65,3.76) | 0.979 |
| LYM, 109 /L | 1.76 (1.42,2.02) | 1.77 (1.26,2.02) | 1.76 (1.49,2.02) | 0.543 |
| MON, 109 /L | 0.31 (0.22,0.45) | 0.26 (0.20,0.47) | 0.31 (0.26,0.45) | 0.776 |
| HB, g/L | 143.00 (130.00,156.00) | 152.50 (128.75,162.50) | 141.00 (130.00,152.50) | 0.233 |
| PLT, 109 /L | 227.00 (200.50,259.50) | 243.00 (194.75,261.75) | 226.00 (200.50,264.50) | 0.745 |
| Blood biochemistry | ||||
| AST, U/L | 21.00 (16.50,25.00) | 22.50 (15.00,32.00) | 21.00 (18.00,23.50) | 0.400 |
| ALT, U/L | 21.00 (14.00,30.00) | 27.50 (19.25,36.25) | 20.00 (13.50,24.00) | 0.286 |
| K, mmol/L | 4.23 (3.98,4.47) | 4.40 (4.27,4.77) | 4.08 (3.92,4.37) | 0.143 |
| Na, mmol/L | 142.10 (140.45,142.70) | 141.05 (139.63,142.10) | 142.30 (141.30,142.95) | 0.141 |
| Cl, mmol/L | 107.30 (105.55,108.80) | 106.40 (104.35,107.68) | 108.00 (106.20,109.30) | 0.135 |
| BUN, mmol/L | 4.26 (3.96,5.64) | 4.07 (3.46,5.07) | 5.19 (4.05,6.09) | 0.132 |
| Cr, μmol/L | 66.00 (56.50,80.00) | 60.50 (55.50,80.75) | 67.00 (58.50,83.00) | 0.484 |
| Myocardial injury markers | ||||
| CK | 107.00 (75.50,143.50) | 99.00 (76.50,171.25) | 107.00 (74.00,134.50) | 0.786 |
| CK-MB | 1.83 (1.20,2.01) | 1.72 (1.16,2.23) | 1.83 (1.20,1.97) | 0.384 |
| LDH | 175.00 (171.00,194.75) | 172.00 (166.00,218.00) | 176.00 (171.00,191.00) | 0.238 |
| Blood coagulation | ||||
| PT | 10.50 (10.25,10.75) | 10.50 (10.33,10.78) | 10.50 (10.15,10.75) | 0.316 |
| APTT | 32.90 (29.55,34.75) | 33.45 (29.08,34.98) | 32.60 (29.55,35.00) | 0.926 |
| D-Dimer | 0.06 (0.04,0.12) | 0.06 (0.04,0.26) | 0.06 (0.04,0.12) | 0.217 |
| Inflammatory markers | ||||
| CRP | 0.85 (0.61,1.72) | 0.86 (0.58,2.80) | 0.81 (0.63,1.39) | 0.152 |
| PCT | 0.05 (0.05,0.05) | 0.05 (0.05,0.05) | 0.05 (0.05,0.05) | 0.149 |
hUC-MSCs human umbilical cord mesenchymal stromal cells, IQR interquartile range, WBC white blood cell, NEU neutrophil, LYM lymphocyte, Mon monocyte, PLT platelet, Hb hemoglobin, ALT alanine aminotransferase, AST aspartate aminotransferase, Cr creatinine, BUN urea nitrogen, PT prothrombin time, CK creatine kinase, CK-MB creatine kinase-MB, LDH lactate dehydrogenase, APTT activated partial thromboplastin time, CRP C-reactive protein, PCT procalcitonin
# hUC-MSCs group compared with control group