Skip to main content
. 2022 Jul 16;13:321. doi: 10.1186/s13287-022-02972-3

Table 4.

Results of lung function test in severe COVID-19 patients were followed at 3 months and 1 year

Parameter Total patients (n = 25) hUC-MSC (n = 8) Control (n = 17) 1-year follow-up
3 Months 1 Year P value 3 Months 1 Year P value 3 Months 1 Year P value Control hUC-MSC P value
VC
VC (Mean ± SD) 2.91 ± 0.74 3.3 ± 0.81 0.055 2.72 ± 0.88 3.14 ± 0.93 0.102 3 ± 0.67 3.35 ± 0.84 0.144 3.35 ± 0.84 3.14 ± 0.93 0.575
VC (% of predicted) 81.4 ± 14.21 101.68 ± 15.84 0.000*** 72.63 ± 9.86 99.75 ± 12.99 0.002** 85.53 ± 14.27 102.59 ± 17.31 0.003** 102.59 ± 17.31 99.75 ± 12.99 0.685
N, ≤ 80% predicted 11(44.0%) 1(4.0%) 0.001** 5(62.5%) 0(0%) 0.026* 6(35.3%) 1(6.9%) 0.085 1(6.9%) 0(0%) 1.000
FVC
FVC (Mean ± SD) 2.83 ± 0.75 3.02 ± 0.78 0.182 2.68 ± 0.89 2.8 ± 0.79 0.507 2.89 ± 0.7 3.12 ± 0.78 0.257 3.12 ± 0.78 2.8 ± 0.79 0.350
FVC (% of predicted) 80.04 ± 14.35 93.24 ± 11.27 0.000*** 72.63 ± 9.46 89.88 ± 9 0.003** 83.53 ± 15.14 94.82 ± 12.12 0.022* 94.82 ± 12.12 89.88 ± 9 0.316
N, ≤ 80% predicted 13(52.0%) 3(12.0%) 0.002** 6 (75.0%) 0(0%) 0.007** 7(41.2%) 3(17.6%) 0.259 3(17.6%) 0(0%) 0.527
FEV1
FEV1 (Mean ± SD) 1.89 ± 0.71 2.54 ± 0.76 0.001** 2.12 ± 0.64 2.37 ± 0.73 0.193 1.78 ± 0.73 2.62 ± 0.78 0.002** 2.62 ± 0.78 2.37 ± 0.73 0.459
FEV1 (% of predicted) 65.84 ± 23.94 90.72 ± 10.97 0.000*** 71.88 ± 8.46 89.13 ± 6.85 0.001** 63 ± 28.31 91.47 ± 12.57 0.001** 91.47 ± 12.57 89.13 ± 6.85 0.628
 ≤ 80% predicted 18(72.0%) 4(16.0%) 0.000 *** 6(75.0%) 0(0%) 0.007** 12(70.6%) 4(23.5%) 0.015* 4(23.5%) 0(0%) 0.283
FEV1/FVC (%) 0.67 ± 0.19 0.84 ± 0.07 0.000*** 0.8 ± 0.08 0.84 ± 0.06 0.186 0.61 ± 0.2 0.83 ± 0.08 0.000 0.83 ± 0.08 0.84 ± 0.06 0.829
 ≤ 70% 12(48.0%) 1(4.0%) 0.000*** 1(12.5%) 0(0%) 1.000 10(58.8%) 1(6.9%) 0.000 1(6.9%) 0(0%) 1.000
PEF 2.82 ± 1.83 4.44 ± 1.42 0.001 3.59 ± 1.81 4.17 ± 1.73 0.391 2.46 ± 1.78 4.58 ± 1.28 0.001 4.58 ± 1.28 4.17 ± 1.73 0.514
PEF (% of predicted) 38.4 ± 27.05 65.92 ± 18.8 0.000 45.5 ± 22.87 62.63 ± 20.03 0.034 35.06 ± 28.84 67.47 ± 18.62 0.001 67.47 ± 18.62 62.63 ± 20.03 0.559
MVV 70 ± 26.49 90.44 ± 25.23 0.005 71.56 ± 39.61 89.44 ± 35.4 0.241 69.26 ± 19.08 90.91 ± 20.14 0.011 90.91 ± 20.14 89.44 ± 35.4 0.895
MVV (% of predicted) 65.32 ± 15.52 86.74 ± 15.94 0.000 67.13 ± 20.16 85.31 ± 17.62 0.014 64.47 ± 13.46 87.41 ± 15.6 0.000 87.41 ± 15.6 85.31 ± 17.62 0.766

VC vital capacity, FVC vital capacity, FEV1 forced expiratory volume in 1 s, PEF peak expiratory flow, MVV maximal voluntary ventilation

*P < 0.05; **P < 0.01; ***P < 0.001