Table 3.

Molecular docking parameters and results of key ingredients binding to hub targets.

Key ingredients	Target	Vina score	Cavity size	Center			Size
				x	y	z	x	y	z
Quercetin	PTGS2	−9.4	4392	13.702	49.228	64.724	21	30	29
	TNF	−8.9	10384	29.389	−21.424	41.646	35	35	35
	IL6	−9.1	2422	−28.73	32.674	41.7	27	21	21
	JUN	−8	1710	−2.548	−5.371	20.862	21	21	32
	IL1B	−6.9	145	−15.895	9.344	−14.260	21	21	21
	CCL2	−7.3	195	−3.977	−17.987	4.759	21	21	21
	IFNG	−7	932	7.332	35.436	22.884	31	21	35
	IL4	−6.9	70	9.769	34.813	−0.368	21	21	21
	IL10	−6.6	73	13.752	61.149	41.144	21	21	21
	CXCL8	−6.2	92	18.369	−13.86	−17.202	21	21	21
Kaempferol	PTGS2	−9.5	5179	11.893	52.644	16.694	33	21	29
	TNF	−9	10384	29.389	−21.424	41.646	35	35	35
	IL6	−8.8	2422	−28.73	32.674	41.7	27	21	21
	JUN	−7.9	1710	−2.548	−5.371	20.862	21	21	32
	IL1B	−6.6	154	−22.700	21.788	−13.997	21	21	21
	CCL2	−7.1	195	−3.977	−17.987	4.759	21	21	21
	IFNG	−7.1	932	7.332	35.436	22.884	31	21	35
	IL4	−6.4	70	9.769	34.813	−0.368	21	21	21
	IL10	−6.7	162	42.705	34.512	43.604	21	21	21
	CXCL8	−6.2	114	17.866	−9.064	−0.582	21	21	21
Wogonin	PTGS2	−9.1	5179	11.893	52.644	16.694	33	26	29
	TNF	−9	10384	29.389	−21.424	41.646	35	35	35
	IL6	−8.3	2422	−28.73	32.674	41.7	27	20	20
	JUN	−8.4	1710	−2.548	−5.371	20.862	20	26	32
	IL1B	−6.4	154	−22.700	21.788	−13.997	20	20	20
	CCL2	−6.4	195	−3.977	−17.987	4.759	20	20	20
	IFNG	−6.8	932	7.332	35.436	22.884	31	20	35
	IL4	−6.2	397	30.6	32.102	12.819	20	20	20
	IL10	−7.1	262	5.253	57.499	35.389	20	20	20
	CXCL8	−6.3	114	17.866	−9.064	−0.582	20	20	20
Formononetin	PTGS2	−9.3	5179	11.893	52.644	16.694	33	21	29
	TNF	−8.2	703	32.132	−11.15	−7.15	21	21	21
	IL6	−8	608	−58.308	−3.426	17.841	21	21	21
	JUN	−7.2	1710	−2.548	−5.371	20.862	21	21	32
	IL1B	−6.5	111	−18.334	4.585	5.997	21	21	21
	CCL2	−6.9	195	−3.977	−17.987	4.759	21	21	21
	IFNG	−7.2	932	7.332	35.436	22.884	31	21	35
	IL4	−5.8	70	9.769	34.813	−0.368	21	21	21
	IL10	−6.9	262	5.253	57.499	35.389	21	21	21
	CXCL8	−6.6	114	17.866	−9.064	−0.582	21	21	21
7-O-Methylisomucronulatol	PTGS2	−8.5	5179	11.893	52.644	16.694	33	21	29
	TNF	−8.1	703	32.132	−11.15	−7.15	21	21	21
	IL6	−8.2	2422	−28.73	32.674	41.7	27	21	21
	JUN	−7.2	1710	−2.548	−5.371	20.862	21	21	32
	IL1B	−6.2	145	−15.895	9.344	14.260	21	21	21
	CCL2	−6.1	195	−3.977	−17.987	4.759	21	21	21
	IFNG	−6.5	3791	−2.13	29.796	34.129	21	35	21
	IL4	−5.6	70	9.769	34.813	−0.368	21	21	21
	IL10	−6.9	162	42.705	34.512	43.604	21	21	21
	CXCL8	−5.6	114	17.866	−9.064	−0.582	21	21	21