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Mean number of injections per period until 48 months (primary outcome). The mean number of intravitreal injections was reduced significantly between 12 and 24 months (P=0.007), between 24 and 36 months (P=0.003), and between 36 and 48 months (P=0.002) compared with the number of injections performed in the first 12 months of follow-up.
