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. 2022 Jun 30;144(2):339–352. doi: 10.1007/s00401-022-02460-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Progression-free (a) and overall (b) survival analysis revealed that high levels of KIRREL2 expression (a cut-off log2 RPKM > 2.5; green line) are significantly associated with worse outcomes in Grp 3 MB (log-rank test; p < 0.01). c–h Scatter graphs show an absence of correlation between KIRREL2 and MYC expression (c; correlation coefficient: − 0.074; p = 0.374), whereas expression of ITPRIPL1 (d), DCAF4 (e), NPW (f), CDT1 (g), MAB21L2 (h) was correlated strongly with MYC expression (all p < 0.01). i. KIRREL2 expression was higher in Grp 3 MB (red boxplot; n = 179) as compared to WNT-MB (violet boxplot; n = 20), SHH-MB (blue boxplot; n = 188) and Grp 4 MB (green boxplot; n = 260) in the current/screening RNA_seq MB set (t-test; p < 0.01). j KIRREL2 expression was also higher in Grp 3 MB (red boxplot; n = 46) as compared to SHH-MB (blue boxplot; n = 51) and Grp 4 MB (green boxplot; n = 188) in independent/validation set generated with Affymetrix platform (t-test; p < 0.01). k. KIRREL2 expression is quite similar in these main second generation II (light-green boxplot), III (dark-green boxplot) and IV (gray boxplot) subgroups which composed 85% of Grp 3 MB (t-test; p = 0.323)