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. 2022 Jun 30;144(2):339–352. doi: 10.1007/s00401-022-02460-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Progression-free (a) and overall (b) survival for Grp 3 MB combining various HIT regimens (RT/CHT vs. CHT alone) and KIRREL2 expression levels. High KIRREL2 was associated with adverse outcomes for patients treated either with CHT alone or combined RT/CHT as compared to those with low levels of KIRREL2