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. 2022 Jun 30;144(2):339–352. doi: 10.1007/s00401-022-02460-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Diffuse KIRREL2 membranous-cytoplasmic immuno-expression in Grp 3 MB accompanied with high gene expression at mRNA level. b Completely KIRREL2-negative Grp3 MB sample with low gene expression at mRNA level. Progression-free (left) and overall (right) survival analysis revealed that KIRREL2 immunopositivity (green line) is significantly associated with worse outcomes in both screening/whole sections (c, d) and validation/TMA sections (e, f) sets of Grp 3 MB (log-rank test; p < 0.01)