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. 2022 May 25;144(2):353–372. doi: 10.1007/s00401-022-02438-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Muscle morphological features of ASyS were similar between serological ASyS subgroups. Analysis of skeletal muscle biopsies by immunohistochemistry (a, b, c, e, g, i). Muscle morphology was quantified and compared between subgroups by semi-quantitative score. Muscle biopsies from anti-Jo-1⁺ (n = 10), PL-7⁺ (n = 6) and PL-12⁺ (n = 8) patients were analyzed. Representative muscle biopsies are displayed (d) for C5b-9, MHC-cl. I and MHC-cl. II for serological subgroups. Scale bar 100 µm. Differences between groups were analyzed using the Kruskal–Wallis test followed by the Bonferroni-Dunn correction for multiple comparisons. The level of significance was set to p < 0.05. *p < 0.05. cl. = class