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. 2022 Jul 16;13:4137. doi: 10.1038/s41467-022-31882-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Schematic illustration on blood circulation test for obtaining blood retention profiles for our nanoparticles. b Blood clearance half-lives of our model nanoparticles. Bar heights are reported as averages of two independent trials (n = 3 biologically independent mice in each independent trial). c Plot on the relationship of blood clearance half-life versus nanoparticle elasticity, using results from this work and prior reports on this topic. d Schematic illustration on in vitro cellular uptake assays. Uptake efficiency of nanoparticles by murine macrophage e RAW264.7 and f Ana-1 cells. Bar heights are reported as averages of two independent trials, while data points are reported as average ± standard deviation (n = 3 in each independent trial). Uptake efficiency of our nanoparticles by adherent g RAW264.7 and h Ana-1 cells in mouse plasma-supplemented culture medium. Bar heights are reported as average of two independent trials, while data points are reported as average ± standard deviation (n = 3 in each independent trial). i Plots on the relationship of normalized cellular uptake relative to the softest particle in a same study versus nanoparticle elasticity, using results from this work and prior reports on this topic. j Schematic illustration on in vitro cellular uptake assays by suspended Ana-1 in mouse plasma-supplemented culture medium. k Uptake efficiency of our nanoparticles by suspended Ana-1 in mouse plasma-supplemented culture medium. Bar heights are reported as average of two independent trials, while data points are reported as average ± standard deviation (n = 3 in each independent trial).