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. 2022 Jul 16;7:16. doi: 10.1038/s41539-022-00133-y

Table 2.

Effects of ablating adult neurogenesis on mood-related behaviours in stressed animals.

Ablation methods Start of ablation Stress model Behavioural Test Effects of ablation on stress-induced changes in behaviour Reference
X-irradiation The 22nd day of stress 5 weeks of UCMS Coat score No effects Zhu et al., 201084
Novelty-suppressed feeding No effects
5 weeks before stress 5 weeks of UCMS Splash test No effects Surget et al., 200878
Novelty-suppressed feeding No effects
5 weeks before stress 10 days of social defeat stress Social interaction test Blocked stress-induced social avoidance Lagace et al., 201052
1 week before stress 4 weeks chronic low CORT Open field test No effects David et al., 200945
Novelty-suppressed feeding No effects
Forced swim test No effects
MAM The 4th week of chronic stress 6 weeks of UCMS Forced swim test No effects Bessa et al., 200970
Sucrose preference test No effects
Novelty-suppressed feeding Aggravated stress-induced anxiety-like behaviour
GFAP-TK animal models Before stress 14 days of social defeat stress Sucrose preference test No effects Schloesser et al., 201043
Light-dark box No effects
Social interaction test No effects
The start of stress 4 weeks of unpredictable restraint stress Novelty-suppressed feeding A trend of decreased anxiety-like behaviour in stressed mice Schoenfeld et al., 201789
Sucrose Preference Test No effects