Table 2.
Effects of ablating adult neurogenesis on mood-related behaviours in stressed animals.
Ablation methods | Start of ablation | Stress model | Behavioural Test | Effects of ablation on stress-induced changes in behaviour | Reference |
---|---|---|---|---|---|
X-irradiation | The 22nd day of stress | 5 weeks of UCMS | Coat score | No effects | Zhu et al., 201084 |
Novelty-suppressed feeding | No effects | ||||
5 weeks before stress | 5 weeks of UCMS | Splash test | No effects | Surget et al., 200878 | |
Novelty-suppressed feeding | No effects | ||||
5 weeks before stress | 10 days of social defeat stress | Social interaction test | Blocked stress-induced social avoidance | Lagace et al., 201052 | |
1 week before stress | 4 weeks chronic low CORT | Open field test | No effects | David et al., 200945 | |
Novelty-suppressed feeding | No effects | ||||
Forced swim test | No effects | ||||
MAM | The 4th week of chronic stress | 6 weeks of UCMS | Forced swim test | No effects | Bessa et al., 200970 |
Sucrose preference test | No effects | ||||
Novelty-suppressed feeding | Aggravated stress-induced anxiety-like behaviour | ||||
GFAP-TK animal models | Before stress | 14 days of social defeat stress | Sucrose preference test | No effects | Schloesser et al., 201043 |
Light-dark box | No effects | ||||
Social interaction test | No effects | ||||
The start of stress | 4 weeks of unpredictable restraint stress | Novelty-suppressed feeding | A trend of decreased anxiety-like behaviour in stressed mice | Schoenfeld et al., 201789 | |
Sucrose Preference Test | No effects |