Fig. 7. KIT expression promotes the formation of stroma-rich tumors in the mouse caecum.

A Schematic overview of orthotopic implantation of PDO2^CONTROL and PDO2^KIT in the submucosa of NSG caecum. B Body weight during the experiment, day 0 is start of the experiment. C Kaplan–Meier curve demonstrating overall survival in PDO2^CONTROL and PDO2^KIT implanted mice. D Tumor take in mice, i.e., successful engraftment of implantation and formed primary tumors. E Histological images of human Nucleoli, pan-Cytokeratin, and KIT in primary tumors derived from mice, which were implanted with PDO2^KIT. Scale bars are 200 and 50 µm.