Table 1:
Baseline Characteristics of Patients with and without Cirrhotic Cardiomyopathy (CCM) By the Original and Revised Definition
Original CCM Definition | Revised CCM Definition | |||
---|---|---|---|---|
Demographic Variables | No CCM (N = 48) | CCM (N = 162) | No CCM (N = 146) | CCM (N = 64) |
Age | 56 | 60 | 58 | 60 |
MELD at Transplant | 29 | 28 | 28 | 28 |
Male Gender | 28 (58%) | 97 (60%) | 94 (64%) | 31 (48%) |
Race | ||||
White | 47 (98%) | 153 (94%) | 141 (97%) | 59 (92%) |
Black | -------- | 6 (4%) | 2 (1%) | 4 (6%) |
Other | 1 (2%) | 3 (2%) | 3 (2%) | 1 (2%) |
Disease Etiology | ||||
Non-Alcoholic Fatty Liver Disease | 8 (17%) | 61 (38%) | 45 (31%) | 24 (38%) |
Alcohol-Associated Liver Disease | 12 (25%) | 39 (24%) | 40 (28%) | 11 (17%) |
Hepatitis C Viral Infection | 13 (27%) | 28 (17%) | 27 (18%) | 14 (22%) |
Other Etiologies | 15 (31%) | 34 (21%) | 34 (23%) | 15 (23%) |
Smoking Pre-Transplant | 18 (38%) | 64 (40%) | 53 (36%) | 29 (45%) |
BMI > 30 Pre-Transplant | 8 (17%) | 79 (48%) | 55 (38%) | 30 (47%) |
Hypertension | 8 (17%) | 27 (17%) | 25 (17%) | 10 (16%) |
Diabetes | 3 (6%) | 29 (18%) | 25 (17%) | 7 (11%) |
Pre-Transplant Statin Use | 6 (12%) | 37 (23%) | 29 (20%) | 14 (22%) |
Pre-Transplant Antiplatelet Therapy | 19 (40%) | 71 (44%) | 59 (40%) | 31 (48%) |
Pre-Transplant Beta Blocker Use | 34 (71%) | 105 (65%) | 97 (66%) | 42 (66%) |
Pre-Transplant Aldosterone Antagonists | 47 (98%) | 133 (82%) | 123 (83%) | 57 (89%) |
Echocardiographic Variables (median) | No CCM (N = 48) | CCM (N = 162) | No CCM (N = 146) | CCM (N = 64) |
Septal e’ (n = 201) | 9.8 | 8 | 8.5 | 7.2 |
Lateral e’ (n = 204) | 12 | 11 | 12 | 9.1 |
Average E/e’ Ratio (n = 201) | 8.9 | 9.1 | 8.5 | 11.9 |
Tricuspid Regurgitant Maximal Velocity (n=183) | 2.5 | 2.5 | 2.4 | 2.8 |
Left Atrium Volume Index (n = 202) | 33 | 28 | 26 | 38 |
Mitral Valve Deceleration Time (n = 209) | 170 | 246 | 218 | 252 |
Ejection Fraction (n = 210) | 66 | 66 | 65 | 67 |
E/A Ratio | ||||
E/A ≤ 0.8 | ------ | 36 (23%) | 23 (16%) | 13 (22%) |
E/A 0.9–1.9 | 43 (90%) | 110 (71%) | 112 (77%) | 41 (71%) |
E/A ≥2 | 5 (10%) | 9 (6%) | 10 (7%) | 4 (7%) |