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Global knockout of Sigmar1 by CMV-Cre. (A) Breeding strategy to generate Sigmar1 global knockout (Sigmar1−/−) mice. (B) Cre-mediated removal of exon 1-4 of Sigmar1 and PCR genotyping of Sigmar1 wild-type (331 bp) and mutant (274 bp) alleles. (C) Western blot analysis of SIGMAR1 expression in retina, hippocampus, cortex and liver tissues from wild type, Sigmar1+/− and Sigmar1−/− mice.
