Table 2.
Changes in estimated mean levels of continuous clinical endpoints over time
| Change in | Visit | Estimated mean and 95% CI | Estimated mean difference from T0 and 95% CI | p-value |
|---|---|---|---|---|
| HbA1c (%) | T0 | 8.55(8.27;8.83) | ||
| T1 | 7.16(6.88;7.44) | − 1.38 ( − 1.68; − 1.09) | < 0.0001 | |
| FBG (mg/dl) | T0 | 186.03 (177.05;195.01) | ||
| T1 | 129.5 (120.52;138.48) | − 56.53 ( − 67.17; − 45.89) | < 0.0001 | |
| BMI (Kg/m2) | T0 | 32.9 (31.81;33.99) | ||
| T1 | 30.73 (29.63;31.82) | − 2.18 ( − 2.56; − 1.79) | < 0.0001 | |
| Weight (Kg) | T0 | 94.23 (90.75;97.72) | ||
| T1 | 88.2 (84.72;91.69) | − 6.03 ( − 7.13; − 4.93) | < 0.0001 | |
| SBP (mmHg) | T0 | 135.82 (133.63;138.01) | ||
| T1 | 133.06 (130.87;135.25) | − 2.76 ( − 4.08; − 1.44) | < 0.0001 | |
| DBP (mmHg) | T0 | 79.57 (78.05;81.08) | ||
| T1 | 75.72 (74.21;77.23) | − 3.85 ( − 5.02; − 2.67) | < 0.0001 | |
| Total chol (mg/dl) | T0 | 190.33 (181.44;199.22) | ||
| T1 | 172.18 (163.29;181.07) | − 18.14 ( − 23.99; − 12.3) | < 0.0001 | |
| HDL-chol (mg/dl) | T0 | 44.84 (42.49;47.18) | ||
| T1 | 47.44 (45.1;49.79) | 2.61 (1.14;4.07) | 0.0006 | |
| LDL-chol (mg/dl) | T0 | 105.49 (97.87;113.12) | ||
| T1 | 94.56 (86.94;102.19) | − 10.93 ( − 16.47; − 5.39) | 0.0002 | |
| TG (mg/dl) | T0 | 199.99 (181.44;218.54) | ||
| T1 | 150.89 (132.35;169.44) | − 49.1 ( − 65.47; − 32.72) | < 0.0001 | |
| Non HDL-chol (mg/dl) | T0 | 145.49 (137.11;153.87) | ||
| T1 | 124.74 (116.36;133.12) | − 20.75 ( − 26.71; − 14.79) | < 0.0001 |
HbA1c Glycated haemoglobin, FBG Fasting blood glucose, SBP Systolic blood pressure, DBP Diastolic blood pressure, chol Cholesterol, HDL High-density lipoprotein, LDL Low-density lipoprotein, TG Triglycerides, 95% CI = 95% confidence intervals
*Values in bold are statistically significant