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. 2022 Jul 16;13:322. doi: 10.1186/s13287-022-03005-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — HucMSCs-EVs exert anti-inflammatory effect by downregulating METTL3 expression in macrophages. A. Western blot analysis of IL-1β and cleaved caspase-1 levels in culture SN and pro-IL-1β, pro-caspase-1, and NLRP3 levels in cell lysates in each group. B. NLRP3 ubiquitination was analyzed in THP-1 cells with different treatments. C. Western blot analysis of METTL3 levels in cell lysates in each group. D. The m6A level of RNA in each group (n = 3). E. Western blot analysis of IL-1β and cleaved caspase-1 levels in culture SN and pro-IL-1β, pro-caspase-1, NLRP3, and METTL3 levels in cell lysates in each group. Data are presented as mean ± SD. ns, no significance; *p < 0.05; **p < 0.01; ***p < 0.001