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. 2022 Jul 16;13:322. doi: 10.1186/s13287-022-03005-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — HucMSCs-EVs facilitate the migration of chondrocyte and inhibit the degradation of ECM by downregulating METTL3 in macrophage. A. Migration of chondrocytes was observed using transwell assay. Scale bar = 200 μm. B. Images of cell scratch area healing assay on chondrocytes were obtained under a light field of microscope at 0 h, 24 h, and 48 h. C. The number of migratory cells was calculated and analyzed in each group (n = 3). Scale bar = 200 μm. D. The healing area of a scratch wound was analyzed in each group (n = 3). E. Western blot analysis for COL2A1, Aggrecan, ADAMTS5, and MMP13 in each group. F. Quantification of the density of immunoreactive bands normalized to tubulin in each group (n = 3). Data are presented as mean ± SD. ns, no significance; *p < 0.05; **p < 0.01; ***p < 0.001