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. 2022 Apr 4;6(7):830–841. doi: 10.1038/s41551-022-00875-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — (a) Expression level of GD2 on NXS2 cells cultured in vitro (C) and isolated form resected NXS2 subcutaneously growing tumours (T). (b) The cytotoxic effect of engineered GD2-targeted murine T cells against NXS2 cells in vitro, and (c) IFN-γ secretion by engineered T cells upon antigen encounter. Error bars represent SEM (n.s.: no statistical significance, ****: P < 0.0001). (d-f) Tumour size of individual mice after treatment with Mock T cells (D), CAR T cells (E), and CAR(NAP) T cells (F). Precise P-values are reported in Supplementary Table 3.