Fig. 1.

Corticosterone suppresses the MAOi-mediated enhancement of inotropic response in mouse hearts. M-mode echocardiography was recorded for 2 min at baseline and for 8 min after each drug administration. The maximal cardiac response was reported. A Representative echocardiography images of WT mouse before and after injection of EPI or DOB (100 µg/kg, i.p.) with and without MAOi pretreatment (0.4 mg/kg, i.p., 5 min). B, C Quantification of mouse cardiac EF and HR as treated in A. D Representative echocardiography images of WT mouse in response to EPI after pretreatment with MAOi and CORTI (200 μg/kg, i.p., 5 min). E, F Quantification of maximal EF and HR in D. Data are shown as mean ± SD of individual mice. n = 9/group, p values were obtained by row-matched (RM) one-way ANOVA followed by Tukey’s test