Table 2:
Risk Factors for Infections Containing a Gram-Negative and AmpCa Organism among SBS Patients Receiving Home Parenteral Nutrition
| Factor | Risk factors for gram-negative infections | Risk factors for AmpC harboring organism infections | ||||
|---|---|---|---|---|---|---|
| Not Gram-negative (n=32) | Gram- negative (n=25) | Multivariablea OR, 95% CI | Not AmpC Organism (n=49) | AmpCb Organism (n=8) | Multivariablea OR, 95% CI | |
| Months of age, median (range) | 35.6 (6.8–252) | 19.6 (7–122) | N/A | 37.1 (6.8–122) | 21.7 (7–252) | 0.96 (0.9–1) |
| Leaking gastric tube in previous thirty days | 9 (28%) | 3 (12%) | 0.2 (0.04–1.4) | 11(22%) | 1(12.5%) | N/A |
| CVL dysfunction in prior 30 days | 17(53%) | 11 (44%) | N/A | 23(47%) | 5(62.5%) | N/A |
| Presence of a salvaged line | 8 (25%) | 12 (48%) | 3.1 (0.8–11.7) | 17(35%) | 3 (38%) | N/A |
| Home ethanol lock therapy | 29 (91%) | 14 (56%) | 0.1 (0.01–0.5) | 38(78%) | 5 (63%) | N/A |
| Home erythromycin therapy | 9 (28%) | 7 (28%) | N/A | 15(31%) | 1(13%) | N/A |
| Absent ileocecal valve | 11 (34%) | 11 (44%) | N/A | 19 (39%) | 3 (38%) | N/A |
| Present gastric-tube | 31 (97%) | 23 (92%) | N/A | 46 (94%) | 8 (100%) | N/A |
| Blood culture with gram-negative bacteria in previous year | 17 (53%) | 11 (44%) | N/A | 23 (47%) | 5 (62%) | N/A |
| Any culture with gram-negative bacteria in previous year | 23 (72%) | 15 (60%) | N/A | 32(65%) | 6 (75%) | N/A |
| Blood culture with inducible AmpCb harboring organism in prior year | 4 (13%) | 1 (4%) | N/A | 4 (8%) | 1 (12%) | N/A |
| Any culture with inducible AmpCb harboring organism in prior year | 7 (22%) | 6 (24%) | N/A | 8 (16%) | 5 (62%) | 9.4 (1.3–68.1) |
| CVL days since placement at the time of infection, median (range) | 125.5 (2–1812) | 158 (11–783) | N/A | 130 (2–1812) | 136 (13–531) | N/A |
SBS, short bowel syndrome; OR, odds ratio, CI, confidence interval; CVL, central venous line
a
AmpC harboring organisms consisted of Enterobacter, Citrobacter, Serratia, and Morganella species
b
The multivariable generalized linear mixed models with logit links only included variables with p<0.2 on univariable analysis, and the outcome of the models were an infection that contained a gram-negative pathogen and an infection that contain an AmpC harboring organism