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Comparative analysis of baseline transcriptomes of radiation-sensitive and radiation-resistant PDO lines. (A) Principal component analysis; (B) Volcano plot of upregulated and downregulated genes in radioresistant PDOs; Gene set enrichment analysis using (C) KEGG pathways, (D) Oncogenic Pathways and (E) Hallmarks pathways gene sets. (F) Heatmap of upregulated PI3K/AKT/mTOR pathway genes in radioresistant PDOs. (PC=principal component, FC=fold change).
