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. 2022 Jul 4;12:920444. doi: 10.3389/fonc.2022.920444

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Copyright © 2022 Wanigasooriya, Barros-Silva, Tee, El-asrag, Stodolna, Pickles, Stockton, Bryer, Hoare, Whalley, Tyler, Sillo, Yau, Ismail and Beggs

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Single-cell RNA sequencing of irradiated PDOs shows cell type specific response to radiation and increase in mTOR activity in radiated cells. UMAP dimensional reduction of single-cell sequencing of irradiated (IRR) and control (CON) radiation sensitive PDOs displayed merged (A) and separately (B). (C) Markers of stem-like and differentiated clusters. (D) Heatmap illustrating pathway responsive genes (PROGENy) for each cell cluster. (E, F) Scalable Bayesian Boolean Tensor Factorisation (SBBTF) and pathway analysis showing enrichment of mTOR activity on irradiated cells. *p < 0.05, **p < 0.01, ***p < 0.001, NS, Not significant.