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. 2022 Jul 4;13:893426. doi: 10.3389/fphar.2022.893426

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Copyright © 2022 Liang, Zhang, Wang, Zhao, Zhou, Feng, Wu, Li, Bai, Zeng, Niu and Miao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Higher severity of UC means lower PARL; PARL level in intestinal mucosa of UC patients decreased, and PINK1 and Parkin level rose. (A–C) Expression level of PARL, PINK1, and Parkin genes in intestinal mucosa of each group were measured by RT-PCR. (D–G) Immunohistochemistry was used to detect level of PARL, PINK1, and Parkin proteins in intestinal mucosa of mice. These data were expressed as means ± standard deviation, and statistical results were obtained by one-way ANOVA. Statistical significance at *p < 0.05, **p < 0.001, ***p < 0.001 and ****p < 0.0001.