Table 4.

Results obtained performing MIL and the barcode analysis on single-scale and multi-scale inputs.

	MIL					Barcode
	5x	10x	20x	5x + 10x	5x + 10x + 20x	5x	10x	20x	5x + 10x	5x + 10x + 20x
Weighted F1	0.88	0.88	0.87	0.90	0.90	0.78	0.70	0.74	0.80	0.73
Macro F1	0.85	0.84	0.82	0.87	0.86	0.68	0.61	0.64	0.71	0.62
MCC	0.87	0.87	0.86	0.90	0.89	0.77	0.69	0.74	0.80	0.73
ACC	0.86	0.64	0.63	0.86	0.78	0.42	0.47	0.47	0.56	0.43
BLCA	0.83	0.83	0.79	0.86	0.83	0.70	0.48	0.69	0.68	0.65
BRCA	0.93	0.94	0.91	0.93	0.93	0.90	0.82	0.84	0.89	0.82
CESC	0.79	0.77	0.73	0.81	0.80	0.53	0.40	0.53	0.57	0.52
CHOL	0.60	0.80	0.55	0.67	0.83	0.22	0.20	0.00	0.25	0.00
COAD	0.93	0.90	0.85	0.96	0.90	0.82	0.75	0.81	0.86	0.77
DLBC	0.80	0.50	0.00	0.50	0.00	0.00	0.00	0.00	0.00	0.00
ESCA	0.68	0.69	0.73	0.74	0.74	0.50	0.35	0.51	0.55	0.53
GBM	0.85	0.90	0.89	0.90	0.91	0.80	0.76	0.80	0.77	0.80
HNSC	0.87	0.89	0.87	0.88	0.89	0.85	0.51	0.61	0.82	0.62
KICH	0.86	0.87	0.98	0.93	0.92	0.89	0.83	0.80	0.89	0.78
KIRC	0.94	0.95	0.93	0.96	0.95	0.94	0.89	0.89	0.93	0.90
KIRP	0.87	0.82	0.81	0.89	0.90	0.83	0.68	0.68	0.90	0.68
LGG	0.92	0.92	0.94	0.94	0.94	0.89	0.86	0.88	0.84	0.87
LIHC	0.93	0.93	0.91	0.92	0.94	0.82	0.81	0.87	0.87	0.86
LUAD	0.81	0.81	0.85	0.87	0.86	0.69	0.56	0.62	0.72	0.59
LUSC	0.77	0.77	0.79	0.82	0.82	0.60	0.54	0.61	0.66	0.60
MESO	0.67	0.67	0.57	0.73	0.83	0.11	0.11	0.29	0.09	0.20
OV	0.98	0.93	0.93	0.98	1.00	0.67	0.67	0.56	0.70	0.56
PAAD	0.90	0.86	0.89	0.93	0.89	0.72	0.55	0.59	0.75	0.42
PCPG	0.97	0.94	0.96	0.96	0.96	0.90	0.84	0.91	0.94	0.92
PRAD	0.94	0.96	0.96	0.97	0.97	0.96	0.97	0.91	0.97	0.88
SARC	0.84	0.80	0.86	0.85	0.85	0.73	0.63	0.70	0.84	0.70
SKCM	0.85	0.90	0.88	0.93	0.92	0.59	0.53	0.59	0.72	0.60
STAD	0.85	0.88	0.86	0.89	0.86	0.66	0.50	0.66	0.73	0.60
TGCT	0.95	0.93	0.95	0.97	0.97	0.87	0.79	0.75	0.89	0.79
THCA	0.97	0.98	0.97	0.96	0.98	0.93	0.95	0.94	0.94	0.94
THYM	0.93	0.96	0.92	0.96	0.96	0.78	0.78	0.78	0.77	0.79
UCEC	0.87	0.87	0.87	0.91	0.89	0.85	0.77	0.77	0.84	0.77
UCS	0.43	0.52	0.70	0.58	0.64	0.22	0.32	0.12	0.45	0.13

The results are obtained by training the model on the entire set of slides, after reserving a 20% split for testing. The value of the best performing magnification (or combination thereof) is highlighted in green. The top 3 rows show the aggregated classification results: weighted F1, macro F1 and MCC scores for the overall classification across all different tumor types on the test set.