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. 2022 Jul 4;13:907145. doi: 10.3389/fgene.2022.907145

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Copyright © 2022 Zhang, Cai, Lu, Xu, Qu, Zhao and Ding.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PPI network, functional enrichment analysis, and potential targeted therapeutics based on SCr-related modules. (A) Interaction network analysis based on WGCNA. Each dot is color-coded by its corresponding module. R-/P-Mod are marked with circles. (B,C) Chord plots of the enriched GO/KEGG/Reactome terms of R- (B)/P-Mod (C). (D) Venn plot depicts the overlap of 19 small molecular compounds identified in both red-module-targeted (Score ≥90) and pink-module-targeted (Score ≥90) compounds. (E) Heatmap of expression pattern scores of 19 targeted compounds in P- and R-Mod, respectively.