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. 2022 Jul 4;13:907145. doi: 10.3389/fgene.2022.907145

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Copyright © 2022 Zhang, Cai, Lu, Xu, Qu, Zhao and Ding.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Space-validation of RFRGs based on The Human Protein Atlas Database and space-time dual-validation of RFRGs based on the Dixon 2021 scRNA-Seq database. (A) Transcriptional distribution of RFRGs in different organs based on datasets in the GTEx database. (B) Immunohistochemical staining of RFRGs depicted specific translational distribution in renal tissue based on The Human Protein Atlas Database. (C) UMAPs of cell type clustering and spatial plots of increased resolution for major cell types. Spatial expression of RFRGs along the female injury time course. Pod, podocytes. PTs12, proximal tubule segments 1–2. PTs3, proximal tubule segments 3. TAL, thick ascending limb. DTL, descending thin limp of loop of Henle. DCT, distal convoluted tubule. PC, principal cells. IC, intercalated cells. Uro, urothelium. Fib, fibroblasts.