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. 2022 Jul 4;3:873157. doi: 10.3389/froh.2022.873157

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Copyright © 2022 Duffin, Duffin and Grootveld.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Acute toxicity and CLD thresholds of fluoride for silver nitrate (SN) and SDF both with and without a sodium fluoride-containing varnish (FV) in (A) non-fluoridated and (B) fluoridated water environments. Treatment comparison against the fluoride Acute Toxicity and CLD Thresholds (including considerations for the ingestion of fluoridated water, or not, and also toothpaste up to the age of 6 years) using 10 μl of 50% (w/v) SN, or 10 μl of 38% (w/v) SDF, and both with and without the application of 20 μl of a 5% (w/v) FV. These plots were derived using the assumption that every tooth is treated for each age group considered, and all ages are within the 3% weight group, to further demonstrate the safety margin in a worst-case-scenario.