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. 2022 Jul 4;3:873157. doi: 10.3389/froh.2022.873157

Table 2.

Fluoride content (mg) based on number of teeth treated and protocol used (SN or SDF, both with and without FV).

Teeth 50% SN 50% SN + 5% FV 38% SDF 38% SDF + 5% FV
1 0.00 0.45 0.59 1.04
2 0.00 0.90 1.18 2.08
3 0.00 1.36 1.77 3.13
4 0.00 1.81 2.36 4.17
5 0.00 2.26 2.95 5.21
6 0.00 2.71 3.54 6.25
7 0.00 3.16 4.13 7.29
8 0.00 3.62 4.72 8.34
9 0.00 4.07 5.31 9.38
10 0.00 4.52 5.90 10.42
11 0.00 4.97 6.49 11.46
12 0.00 5.42 7.08 12.50
13 0.00 5.88 7.67 13.55
14 0.00 6.33 8.26 14.59
15 0.00 6.78 8.85 15.63
16 0.00 7.23 9.44 16.67
17 0.00 7.68 10.03 17.71
18 0.00 8.14 10.62 18.76
19 0.00 8.59 11.21 19.80
20 0.00 9.04 11.80 20.84
21 0.00 9.49 12.39 21.88
22 0.00 9.94 12.98 22.92
23 0.00 10.40 13.57 23.97
24 0.00 10.85 14.16 25.01
25 0.00 11.30 14.75 26.05
26 0.00 11.75 15.34 27.09
27 0.00 12.20 15.93 28.13
28 0.00 12.66 16.52 29.18
29 0.00 13.11 17.11 30.22
30 0.00 13.56 17.70 31.26
31 0.00 14.01 18.29 32.30
32 0.00 14.46 18.88 33.34

From this table, clinicians can readily determine how much fluoride (in mg) is potentially available for ingestion, depending on the number of teeth being treated and which protocol is being employed. Once the quantity of fluoride in mg has been determined, it can be used in the “plug-and-play” plot option (Figure 4), along with the child's weight, to determine if the amount of fluoride to be administered is above or below the Acute Toxicity and CLD Thresholds. This table was designed assuming an application volume of 10 μL of 50% (w/v) SN, 10 μl of 38% (w/v) SDF, and/or 20 μl of 5% (w/v) FV. The amount of fluoride in 38% (w/v) SDF was calculated using the higher limit of the fluoride content range present in different SDF products [5.0–5.9% (w/v)] to again demonstrate the safety margin in a “worst-case-scenario.” The total amounts of fluoride present in 3.00 and 8.00 mL volume bottles of a well-known SDF product containing 38% (w/v) of this agent (Advantage Arrest) is 177 and 472 mg, respectively.