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. 2022 Jul 4;10:868029. doi: 10.3389/fcell.2022.868029

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Copyright © 2022 Martin and Johnstone.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationships of the trabecular meshwork and flap-like extensions at collector channels. (A–C) Merged confocal CD31 (red) and native fluorescence (green) channel images demonstrate relationships of the trabecular meshwork (TM), Schlemm’s canal (SC), collector channels (CC), and flap-like extensions (FLE) at CC ostia (CCO). Serial images demonstrate a funnel region (F) that becomes cylindrical, forming a SC inner wall valve-like structure (SIV) that attaches to a FLE at the SC external wall. A CCO is visible and distal to the FLE, and a deep scleral plexus (CDSP) is seen. In (A,B), an SC area leading to an intrascleral channel (ISC) has two individual endothelial cell layers in apposition (AP) consistent with a closed potential space. TM attachments to the scleral spur (SS) are visible (B,C). (D) 3D projection of the 22 µm 2D region in (A–C) demonstrates the complex intrascleral vasculature of the SC and ISC connection #21L4-4.