FIGURE 10.

Summary of the transcriptional effects of hypergravity discovered in this study. Turnovers that are increased (red) and decreased (blue) by altered gravity are indicated by arrows. Effects that could be fully demonstrated are displayed as solid lines; effects that could be postulated are indicated by dashed lines. The placement of items does not necessarily reflect the location in the cell. For reasons of simplicity, not all connectors are shown, e.g., translation of alternatively spliced RNA transcripts. Alternatively spliced transcripts are composed of transcripts with and without altered PCCR, and include, but are not limited to, nucleolar-associated transcripts and transcripts from the cytoskeletal nuclear mechanical axis. (A) Steady state. (B) Early effects that could be detected at 3 min of hypergravity. (C) Late effects/long-lasting effects that could be detected after 15 min of hypergravity.