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. 2022 Jul 4;10:933984. doi: 10.3389/fcell.2022.933984

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Copyright © 2022 Vahlensieck, Thiel, Pöschl, Bradley, Krammer, Lauber, Polzer and Ullrich.

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Global dynamics of the effects of hypergravity on the spliced and unspliced transcript pool. (A) Temporal coherence of gene expression in the spliced and unspliced pool, analogously to Figure 1C. Again, the fraction of genes that were consistently regulated in one direction was very small. The initial regulation pattern after 3 min was not symmetric anymore but showed a preference for downregulation for the spliced fraction and a strong preference for upregulation for the unspliced fraction. (B) Overlap between spliced (strong colors) and unspliced (light colors) fractions for all genes, only upregulated, and only downregulated genes for all three temporal comparisons. The fraction of unspliced differentially expressed genes (DEGs) was small compared to spliced DEGs after 3 min and became larger in the following comparisons. This was mostly driven by the low number of downregulated unspliced genes after 3 min but not by upregulated genes after 3 min.