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. 2022 Jul 4;12:901705. doi: 10.3389/fonc.2022.901705

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Copyright © 2022 Shen, Li, Li, Ma, Tao, Zhang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The CXCL12-CXCR4 axis is involved in the role of sinomenine hydrochloride in the proliferative activity of hepatocellular carcinoma (HCC) cells. (A) 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di- phenytetrazoliumromide (MTT) assay to assess the viability of SK-Hep1 cells exposed to diverse levels of sinomenine hydrochloride. (B) Western blot (WB) to detect the expression of CXCL12 and CXCR4 in SK-Hep1 cells. (C) Decrease of CXCR4 expression by siCXCR4 in SK-Hep1 cells, SK-Hep1 cellular activity was identified via CCK-8 analysis. (D) SK-Hep1 cellular activity was identified in SK-Hep1 cells by overexpressing CXCR4, Cell Counting Kit-8 (CCK-8) assay. (E, F) CCK-8 assay measures cell viability. *P < 0.05, **P<0.01.