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CXCL12-CXCR4 axis was involved in the effect of sinomenine hydrochloride on HCC cell apoptosis. CXCR4 knockdown and overexpression were detected in SK-Hep1 cells. (A, B) WB was utilized to identify the expression of apoptotic protein in SK-Hep1 cells. (C, D) Programmed cell death was identified via flow cell technique. *P < 0.05, **P < 0.01.
