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. 2022 Jul 4;12:901705. doi: 10.3389/fonc.2022.901705

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Copyright © 2022 Shen, Li, Li, Ma, Tao, Zhang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The CCL21-CCR7 axis participates in the effect of sinomenine hydrochloride on HCC cells. (A) WB assay of the expression of CCR7 and CCL21 in SK-Hep1 cells. (B, C) CCK-8 experiments examine the effect of CCR7 knockout and CXCR7-overexpressing cells on cell proliferation. (D, E) CCK-8 experiments on the effect of CCR7-transfected SK-Hep1 cells on cell proliferation in the presence of CCL21 (80 ng/ml). (F, G) WB assay of apoptosis-related protein expression in SK-Hep1 cells. (H) Apoptosis was detected by flow cytometry. (I) Transwell assay for cell invasion (×200). *P < 0.05, **P < 0.01.