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. 2022 Jul 4;12:901705. doi: 10.3389/fonc.2022.901705

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Copyright © 2022 Shen, Li, Li, Ma, Tao, Zhang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interfering with tumor-derived DNA by sinomenine hydrochloride affects the ERK/MMP signaling pathway through the CCL21-CCR7 axis in HCC cells. (A) The expression of p-ERK1/2, MMP2, and MMP9 proteins in SK-Hep1 cells after siCCR7 transfection. (B) The expression of p-ERK1/2, MMP2, and MMP9 proteins in SK-Hep1 cells after CCR7-OE transfection. *P < 0.05(compared with NC), ^#P<0.05(compared with DNA+SIN group).