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. 2022 Jul 4;13:862204. doi: 10.3389/fphar.2022.862204

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Copyright © 2022 Du, Li, Song, Wang, Dong, Zhan, Li and Liang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activation of AMPK alleviated MIRI in isolated mouse hearts. (A) AICAR improved the LVSP. (B) Representative images of tissue sections stained with TTC to detect the myocardial infarct size. (C) AICAR decreased the incidence of malignant arrhythmia. (D,E) AICAR decreased the levels of CK and LDH in coronary effluent fluid. (F–H) AICAR decreased the mRNA expression of TNF-α, IL-1β and IL-6 in myocardium tissue. (I,J) Measurement of SOD and MDA levels in the myocardial homogenate. The data were expressed as mean ± SEM (n = 10 per group). **p < 0.01, *p < 0.05 vs. Control group; ^▽▽ p < 0.01, ^▽ p < 0.05 vs. Control + AICAR group; ^## p < 0.01, ^# p < 0.05 vs. I/R group.