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. 2022 Jul 4;10:914450. doi: 10.3389/fbioe.2022.914450

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Copyright © 2022 Nguyen, Wei, Nakada, Zhou and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cardiomyocytes in the CM1 cluster could be partitioned into CM2- and CM10-like subpopulations. (A) snRNA-seq data for CM1 cardiomyocytes in AR_P1-P28 hearts and for CM2 and CM10 cardiomyocytes in AR_P1MI_P28-P30 hearts were evaluated with a semisupervised learning model to calculate a rescaled score for each CM1 cardiomyocyte. Cardiomyocytes with rescaled scores approaching 0 were designated CM1a (CM2-like) and cardiomyocytes with rescaled scores approaching 1 were designated CM1b (CM10-like). (B) The abundance of ATF3, NR4A3, PRKAG2, RGS6, and TMEM126A RNA transcripts was measured in CM1a, CM1b, CM2, and CM10 cardiomyocytes. (C) The proportion of PRKAG2+NR4A3+ATF3+ cardiomyocytes in CM1 (AR_P1-P28), in comparison with CM2 proportions.